Analysis of the action of wheat oligopeptides

June 26, 2024

1. National announcement

On August 28, 2012, the Ministry of Health issued a notice on approving medium and long chain fatty acid edible oils and wheat oligopeptides as new resource foods (Ministry of Health Announcement No. 16 of 2012), officially approving wheat oligopeptides as new resource foods, and providing the following explanations on their sources, processes, consumption levels, quality requirements, and applicable populations.

2. Amino acid composition of wheat oligopeptides

According to Table 1, wheat oligopeptides contain abundant amino acids, with 8 essential amino acids and 2 semi essential amino acids containing 20.24% and 4.11%, respectively, accounting for 24.35% of the total amino acids. The highest content of glutamic acid was 35.12%, followed by proline, leucine, and serine.
Total glutamic acid (glutamic acid+glutamine) is a characteristic amino acid component of wheat oligopeptides.

Glutamine plays a crucial role in the metabolism of organisms and can be said to be a conditionally necessary formic acid. The gastrointestinal tract is the main organ for the utilization of glutamine, and the intestine neither synthesizes nor stores glutamine. It must rely on other organs to synthesize and exogenous glutamine. Wheat oligopeptides can provide rich glutamine to the human body.

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3. The role of glutamine

(1) Promote protein synthesis within muscle cells, promote the growth and differentiation of muscle cells; Stimulate the secretion of growth hormone, insulin, and testosterone, putting the body in a synthetic state, thereby increasing strength and improving endurance.
(2) Enhance the function of the immune system.
(3) Maintain the integrity of the gastrointestinal mucosal structure.
(4) Participate in the synthesis of glutathione (an important antioxidant).
(5) Improve brain function, maintain normal function of kidneys, pancreas, gallbladder, and liver.

Given this, it is essential to obtain sufficient amounts of glutamine through diet. Wheat oligopeptides are an effective way to supplement glutamine.

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4. The role of wheat oligopeptides

1. Enhance immunity

The immune system is an important system in the body that executes immune responses and functions, composed of immune organs, immune cells, and immune substances. Wheat oligopeptides can promote the proliferation of T lymphocytes and enhance cellular immunity; Improve the level of antibodies in body fluids and enhance the immune function of body fluids; Enhance macrophage function; Enhance the activity of NK cells (natural killer).

2. Relieve physical fatigue

There are two main mechanisms by which wheat oligopeptides can resist fatigue:
One is that wheat oligopeptides can promote the repair of damaged skeletal muscle cells and maintain the integrity of skeletal muscle cells, which is a prerequisite for delaying fatigue occurrence.
Secondly, wheat oligopeptides can reduce the generation of oxygen free radicals in myocardial mitochondria, maintain the normal morphology and function of myocardial mitochondria, protect the heart, improve hypoxia tolerance, thereby improving the body's endurance and playing a certain role in reducing fatigue.

3. Protecting gastrointestinal mucosa

Wheat oligopeptides have a certain promoting effect on the growth of gastric mucosal epithelial cells, and wheat oligopeptides can promote the growth of duodenal mucosal cells. The surface epithelial cells are denser and arranged more neatly, and the morphology of epithelial cells is plump.

4. Auxiliary blood pressure lowering effect

Wheat oligopeptides achieve blood pressure lowering function by inhibiting the activity of angiotensin converting enzyme (ACE).
ACE plays an important physiological role in regulating blood pressure in the renin angiotensin system. Renin acts on angiotensinogen, releasing inactive angiotensin I, which generates angiotensin II through the action of ACE, causing an increase in blood pressure.

The peptide segments in wheat oligopeptides with blood pressure lowering function inhibit the activity of angiotensin-converting enzyme (ACE), preventing the transformation of angiotensin type I to type II, thereby inhibiting peripheral vascular constriction and preventing blood pressure elevation, thus making wheat oligopeptides exhibit a certain degree of blood pressure lowering effect.

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5. The application prospects of wheat oligopeptides

1. Sports drinks

According to the provisions of GB 15266 Sports Beverages, sports drinks are beverages that can adapt to the physiological characteristics of people who exercise or engage in physical activity, replenish water, electrolytes, and energy for the body, and can be quickly absorbed.
Glutamine is the most abundant amino acid among the free amino acids in skeletal muscle cells, accounting for 62% of the total free amino acids. During exercise, the human body is in a state of stress, and a large amount of glutamine is outputted from skeletal muscle cells. Timely and appropriate supplementation of glutamine can effectively prevent the breakdown of muscle proteins and increase cell volume through cell hydration, promoting muscle growth. However, glutamine is unstable and difficult to directly apply in beverages. Adding wheat oligopeptides can meet the demand for glutamine in sports drinks.

2. Brain building products

Brain building foods usually refer to foods that have a nourishing effect on the human brain. The main components of the human brain are proteins, lipids (mainly phospholipids), and microorganisms such as B1 and niacin. Especially for students and other people who frequently use the brain, their dietary nutrition should not only meet the calorie needs of the brain, but also pay special attention to the sufficient supply of nutrients.
Wheat oligopeptides contain various amino acids required by the human body, particularly rich in glutamine, which can maintain brain ammonia balance and serve as a precursor for neurotransmitters. Therefore, wheat oligopeptides can be used to develop brain building products.

3. Health food

Wheat oligopeptides have broad application prospects in the field of health products with functions such as anti fatigue, enhancing immunity, lowering blood pressure, lowering blood lipids, and lowering blood sugar.

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2024-06-26

Shaanxi Huike Botanical Development Co., Ltd.

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Ms. Anne

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