As a potential anti-aging ingredient, can NMN once again ignite a craze?
May 15, 2024
At the FIC2024 exhibition held in March this year, Zhongke Xinyang launched its first fully synthesized NMN from a microbial cell factory( β- Nicotinamide mononucleotide has attracted the attention of many businesses and consumers. In fact, as a potential food additive, NMN has been used as a food ingredient or natural health product ingredient in countries such as Japan and Canada to enhance human immunity, gene repair ability, and metabolic capacity. Against the backdrop of global economic growth and deepening population aging, anti-aging is no longer just a necessity for middle-aged and elderly people, but also extends to the post-90s and post-00s groups. NMN is expected to become a star among the "anti-aging" ingredients.
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NMN - Emerging anti-aging star ingredients
NMN, full name[ β- Nicotinamide mononucleotide is a naturally occurring bioactive nucleotide and an important supplement to NAD+(nicotinamide adenine dinucleotide). NMN has been shown to increase the level of NAD+in human cells and has certain benefits in delaying cell aging. NMN exists in various organisms, such as fruits and vegetables. At the same time, NMN is also an inherent substance in the human body, widely involved in multiple biochemical reactions and closely related to human immunity and metabolism. "Anti aging" is a significant characteristic of NMN. Multiple studies have shown that NAD+depletion is closely related to stem cell aging and mitochondrial metabolic disorders. As age increases, the level of NAD+in the human body gradually decreases, leading to weakened cell function and triggering a series of aging symptoms, such as muscle degeneration, decreased brainpower, darkened pigmentation, and hair loss. There is experimental evidence that promoting NAD+levels is considered an effective way to delay aging, and supplementing NMN can accelerate the elevation of NAD+levels in the human body, repair damaged cells, and enhance the immune system. In addition to its anti-aging properties, NMN has also been proved to be beneficial to protecting the heart, preventing diabetes and Alzheimer's disease, improving human metabolism, enhancing cardiovascular health and reducing inflammation. According to business research data, the global NMN market size in 2022 was $356.1 million, and it is expected to reach $1.86777 billion by 2031, with a compound annual growth rate of 20.2% during the forecast period. 02
NMN products have been widely used abroad
Due to the low content of NMN in most organisms, it is necessary to supplement it through diet in order to increase the level of NMN in the human body. At present, the main method for artificially preparing NMN is biosynthesis. Currently, there are countries such as Japan and Canada that explicitly use NMN as a food ingredient or natural health product ingredient. In Japan, companies that produce and develop NMN health products include Meiji Pharmaceutical Co., Ltd., LEVANTE, ATRITENA, and others. Meiji Medicine NMN 10000 Supreme MSNS is a health product manufactured by Japanese pharmaceutical company Meiji Pharmaceutical Co., Ltd. The design purpose of this product is to help promote the health and energy metabolism of human cells, which may have anti-aging effects. The product details page introduces that the NMN purity of this product exceeds 95%. LEVANTE from Nagoya, Japan has launched an NMN anti-aging supplement, which uses yeast fermentation method. The raw materials include NMN, vegetable oil containing Vitamin E, red wine extract powder containing resveratrol, coenzyme Q10, Echinacea extract (Echinacea extract, dextrin), royal jelly α- Lipoic acid, aloe vera powder */cellulose, etc. In 2021, the Canadian Natural Health Products Database listed NMN as a natural health product ingredient, and NMN dietary products can be legally sold in Canada. Canadian brand Prairie Naturals has launched an NMN supplement consisting mainly of NMN, resveratrol, and quercetin. This product can help the elderly population restore cellular health and prevent age-related diseases. In China, NMN cannot be produced and operated as food, but it has become an emerging raw material in the cosmetics industry. According to data from the National Medical Products Administration, as of May 13th, there have been 10 records of new cosmetic raw materials filed by NMN, including well-known companies such as Huaxi Biotechnology Co., Ltd. and Shenzhen Weiqi Technology Co., Ltd. In the field of cosmetics, NMN is mainly used as a skin protector, moisturizer, anti wrinkle agent, and antioxidant. At present, domestic e-commerce platforms have sold NMN water cream, NMN facial mask and other popular products. It is worth mentioning that according to the domestic WeChat search volume index, NMN has experienced significant fluctuations in the index over the past year. Its search volume reached its peak in September 2023 and showed significant growth in March and May 2024, indicating that NMN's popularity has always existed but is not stable.
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NMN becomes a potential homologous ingredient in cosmetics and food
In recent years, the concept of NMN has been very popular in China. However, due to the lack of efficacy verification, relevant regulatory development, and false advertising such as "anti-aging drugs", NMN's further development in the domestic food industry is hindered. However, with the relaxation of the registration application for NMN as a cosmetic ingredient in China, NMN is expected to further gain regulatory recognition in the food industry in the Chinese market in the future. Many industry insiders believe that NMN may become the next potential ingredient in cosmetics and food. In addition, with the continuous improvement of people's health standards, the big health industry will continue to maintain a growth trend for a considerable period of time, and the prospects of the NMN market will become increasingly promising. According to business research's insights into market regions, globally, the Asia Pacific region is facing a serious problem of aging population, and people's interest in combating aging supplements is increasing. In addition, the Asia Pacific region has a long history of using traditional medicines and supplements, which will also promote the popularity of NMN. Regarding the emerging raw material of NMN, the State Administration for Market Regulation has made a clear statement in its response to Proposal No. 1067 of the Fourth Session of the 13th National People's Congress: Currently, the positioning and safety of NMN as a food raw material are not clear, and there is a lack of national food safety standards. It is recommended to conduct safety assessments or clarify national food safety standards based on new food raw materials. Although NMN cannot yet be used as a food ingredient in China, the enthusiasm of Chinese enterprises for developing NMN remains undiminished. For example, Gene Harbor, a Hong Kong based enterprise in China, has successfully launched a patented technology for all natural and green production of NMN. By utilizing the development of new biocatalysts (enzymes), it has created an in vitro enzyme production system with original intellectual property rights, replacing in vivo fermentation processes with in vitro enzyme methods, and successfully reducing industrial production costs. Developed more than ten products, including NMN, glutathione, adenosine, and methionine. Through independent research and development, Zhongke Xinyang has successfully utilized a microbial cell factory to achieve full synthesis of NMN. This not only improves the purity and stability of the product, but also significantly reduces production costs, which is expected to bring a new transformation to the anti-aging market. According to the relevant person in charge of Zhongke Xinyang, Zhongke Xinyang's NMN products can be sold to many overseas markets such as North America and Australia, mainly used in the field of health products. Against the backdrop of continuous technological progress and market advancement, NMN anti-aging products will show even broader development space in the future.
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2024-05-15
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