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The dry powder needle is to quickly freeze the sterile solution of the medicine to about 40 degrees Celsius, and then slowly heat under vacuum to make the water of the solution sublimate while maintaining the frozen powder injection. The common production process is as follows: firstly, the medicine is made into a liquid medicine according to the standard of water injection, and the impurities and bacteria are removed by filtration and ultrafiltration in a state of 100, and the bottle is semi-plugged aseptically, and is quickly frozen in a freeze dryer. When the temperature is below 40 degrees, the liquid is solid. In this state, the ultimate vacuum (<0.009Pa) is used to sublimate the water, and the drug is crystallized and dried into a bulky crystal. After the sublimation is completed, it is automatically stoppered under vacuum. Crystallized freeze-dried powder needles with bacteria, vacuum and water content <0.01% were produced. Therefore, the general freeze-dried powder needle on storage does not need to be refrigerated, and can be stored at room temperature.
The freeze-dried powder needle has good stability compared with the general powder needle and water injection: because the freeze-dried powder needle is made and stored under vacuum, the vacuum state is almost no oxygen, the medicine will not be oxidized; the water content of the freeze-dried powder needle Very low (<0.01%), will not be hydrolyzed; freeze-dried powder needle production process is strictly sterile (up to 100 standards), will not be contaminated, so freeze-dried powder needle stability. The freeze-dried powder needle also has a faster effect than the general powder needle and has high bioavailability. This is because the special production process of freeze-dried powder needles allows the drug to be evenly dispersed in the ice shelf formed by lyophilization such as chitosan. This structure enlarges the surface area of the drug, so that the drug can contact more germs per unit time. Thereby having a quick function. The special ice shelf structure formed by chitosan allows the drug to exist in the nanocapsules in a single microcapsule, which is released as the blood circulation reaches the lesion site, which improves the bioavailability of the drug.
The high-tech of freeze-dried powder needles is as follows: freeze-dried powder needles are vacuum-free, sterile, extremely low in water content, quick-freezing in the production process, high-tech content such as sublimation, and the following high-tech content:
(1) Microencapsulation or formation of liposomes: by screening lyophilized carriers, adjusting the shape of ice shelves and the size of micropores, the drugs can be microencapsulated or formed into liposomes by screening different microcapsules and lipids. The plastids allow the drug to achieve rapid, targeted or controlled release.
(2) By adjusting the carrier and freeze-drying process, the two drugs can be combined into a double salt under specific environmental conditions, the latter can make the two drugs reach the lesion at the same time, play a synergistic effect, and greatly improve the bactericidal efficacy of the antibacterial drug. . And the double salt enhances the stability of the drug.
Shaanxi Huike Botanical Development Co., Ltd. a integrated enterprise which is focus on natural products, Plant extract related products and services.We mainly focus on pharmaceutical, functional food, Freeze-dried powder,Natural Pigment,Homology of medicine and food,beverages and other business services.
For more information about inulin, please contact us!
Email:marketing@huikes.com
2022-8-30
Shaanxi Huike Botanical Development Co., Ltd.
August 12, 2024
August 06, 2024
August 22, 2023
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