Can Senna leaf extract treat constipation?

June 13, 2022

Senna leaf extract has the functions of purging heat and stagnation, laxative, and diuresis. It is mainly used to treat heat accumulation, constipation, abdominal pain, and swelling.

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1. Antibacterial effect
The 10% senna leaf extract has obvious inhibitory effect on Escherichia coli, Proteus, Shigella, Streptococcus A, and S. albicans. Some hydroxyanthraquinones in senna leaf have a certain antibacterial effect. The alcohol extract of Senna ovata has inhibitory effect on a variety of bacteria such as Staphylococcus, Diphtheria, Typhoid, Paratyphoid, Escherichia coli, etc. The water extract is only effective against Typhi. Senna leaf water extract (1:4) has inhibitory effect on dermatophytes such as Bacillus audulans and Nocardia stellaris in vitro.
2. Hemostatic effect
Oral administration of senna powder can increase platelets and fibrinogen, shorten coagulation time, recalcification time, thromboplastin time and clot contraction time, and help stop bleeding. Crystal fibers and calcium oxalate clusters in senna have local hemostatic effects. The 30% senna water extract was directly sprayed on hemorrhagic disease Du under the direct vision of fiberoptic gastroscope, which showed immediate hemostatic effect. After oral administration of 1 g of senna leaf powder to patients with acute bleeding, gastroscope observation was performed, and it was found that senna leaf powder was evenly distributed on the surface of the bleeding lesions (including cancer hemorrhagic disease) and played a good role in hemostasis. It can be considered that the hemostatic effect of senna on acute gastric and duodenal bleeding can promote internal coagulation and anti-fibrinolysis, and at the same time have local effects. The total anthraquinone glycosides (sennoside) extracted from senna leaves were subjected to cross-sectional hemostatic test on mice. The experimental results showed that sennoside had obvious hemostatic effect, and the hemostatic effect of high dose and low dose was almost the same, suggesting that a small dose To achieve hemostatic effect.
3. Effects on the digestive system
The metabolic activation of sennoside C in mice has a synergistic effect with anthrone. Senna is a laxative. Recent studies have found that this drug can not only stimulate the release of PG from the colonic mucosa (and it is believed that this is a mechanism of diarrhea), but also can significantly increase the level of PG in the gastric body and antrum of rats. Increase. 10% senna decoction can significantly reduce the gastric mucosal injury caused by oral administration of 0.6NHCl and subcutaneous injection of 20mg/kg of indomethacin in rats. In the gastric mucosal injury model induced by the same 0.6NHCl, the animals pre-administered with a small dose (5mg/ml) of indomethacin did not have a protective effect on gastric mucosa by senna. Because a small dose of 5 mg/ml indomethacin can significantly inhibit the commissure of PG in the rat stomach within 1 hour without damaging the mucosa, this indirectly proves that senna may protect the gastric mucosa by stimulating the synthesis of PG in the stomach. of. Senna can prevent the damage of high-dose indomethacin on gastric mucosa, possibly because it can antagonize the latter's inhibitory effect on gastric mucosal cyclooxygenase (PG synthase), while pre-indomethacin-treated rats, senna The laxative leaf has no protective effect on gastric mucosal injury caused by 0.6NHCl, which may be due to the inhibition of cyclooxygenase. Because the purgative effect of PG is also a protective effect on the intestinal tract, senna has a protective effect on the gastric mucosa by stimulating the synthesis of PG, which is consistent with the purgative effect of stimulating the synthesis of PG. The effects of rhubarb extract total senna glycosides (sen) on spontaneous electrical activity in guinea pig colonic zone cells were studied by intracellular micro-electroplate technology, indicating that the drug can promote cell membrane depolarization, accelerate the release of slow-wave potential, and significantly increase the The firing frequency of spike potential, Sen (20mmol/L) can induce spontaneous spike potential, this result provides direct evidence at the cellular level for total senna glycosides to promote intestinal peristalsis.
4. Muscle relaxation and antispasmodic effects
Senna has a curare-like effect that blocks acetylcholine at motor nerve endings and skeletal muscles, thereby causing muscle relaxation. Certain hydroxyanthraquinones in senna leaf have a certain antispasmodic effect.
5. Other functions

The seeds of senna auricularia can reduce fasting blood sugar in dogs, and the grass also contains cardiac glycosides (sennapri-rin).

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2022-6-13

Shaanxi Huike Botanical Development Co., Ltd.

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Ms. Anne

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