Efficacy of Centella Asiatica Extract

April 29, 2022

Centella asiatica, Latin name: Centella asiatica (L.) Urban

Centella asiatica extract is obtained by extracting the dried whole grass of Centella asiatica. Its main active components are madecassoside, madecassoside, madecassic acid and madecassolic acid; among them, madecassoside and hydroxy Asiaticoside belongs to triterpenoid saponins, and asiatic acid and madecassic acid belong to triterpene acid compounds; in addition, Centella asiatica extract also has an important component, TECA, which is three kinds of high-purity centella asiatica extracts. A mixture of terpenoids (asiaticoside, madecassic acid, and madecassic acid).

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Efficacy of Centella Asiatica Extract
1. Moisturizing
Because Centella asiatica extract contains triterpenoid saponin compounds, Centella asiatica triterpenoid saponin is a hydrophilic sugar chain, mainly glucose and rhamnose, which can combine with water in the occlusive layer to improve the barrier ability of the epidermis, Enhances skin moisture and can significantly increase the hydration level of the stratum corneum.
A skin test experiment was conducted on 25 volunteers. The lotion and hydrogel containing Centella asiatica extract and the placebo group were applied to different skin parts, twice a day, for 4 weeks. The experiment observed a significant increase in the hydration of the stratum corneum after the first week of application of cosmetic products containing 2.5% and 5% Centella asiatica extract. Among them, the cosmetic preparation containing 5% Centella asiatica extract has the best effect. The lotion containing 5% Centella asiatica extract resulted in a 12% increase in skin stratum corneum moisture, and the hydrogel containing 5% Centella asiatica extract increased 10% compared to the control group and placebo.

2. Quick Fix
Centella asiatica extract can stimulate fibroblast proliferation and activate the SMAD signaling pathway, increasing the production of type I collagen, thereby promoting wound healing and reducing the formation of stretch marks. Centella asiatica extract can significantly promote the deposition of extracellular matrix proteins, it can promote the proliferation of fibroblasts, increase the synthesis of collagen, reduce the activity of metalloproteinases, thereby increasing the deposition of collagen and intracellular free protease amino acid levels.

3. Anti-inflammatory and anti-allergic
Studies have shown that TECA can inhibit the inflammatory response induced by LPS and effectively reduce the level of IgE and the release of inflammatory cytokines (IgE can induce mast cell activation and release a variety of allergic mediators, such as cytokines, histamine, etc.). In addition, TECA can also inactivate macrophages in the skin, thereby reducing skin inflammation and atopic responses. Therefore, Centella asiatica extract has the effect of relieving the symptoms of facial acne, redness, allergies, etc.

4. Anti-aging

Studies have shown that Centella asiatica extract can affect the ultrastructure of fibroblasts, increase the synthesis of DNA in fibroblasts, promote the proliferation of fibroblasts, and promote the synthesis of collagen in fibroblasts. In addition, Centella asiatica extract can promote the biosynthesis of proline, cartilage sulfate and heparan sulfate. The most intuitive manifestation of this series of reactions is to enhance the vitality of cells in the basal layer of cells and maintain skin elasticity and firmness.

Shaanxi Huike Botanical Development Co., Ltd. a integrated enterprise which is focus on natural products, Plant extract related products and services.We mainly focus on pharmaceutical, functional food, Freeze-dried powder,Natural Pigment,beverages and other business services.

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2022-4-29

Shaanxi Huike Botanical Development Co., Ltd.

Author:

Ms. Anne

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