Ergot sulfur, which has the same origin as makeup and food, may become the next anti-aging dark horse

June 20, 2024

In recent years, the "elixir of aging" NMN (nicotinamide mononucleotide) has sparked several investment frenzies in the capital market. However, with the strengthening of regulatory oversight, NMN has been controversial in the domestic health product market. Especially in recent times, customs policies have further tightened the import supervision of NMN. Prior to the 618 promotion, NMN was explicitly prohibited from entering bonded warehouses, which undoubtedly added insult to injury to the already restricted market.

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Why is NMN so restricted in the domestic market? On the one hand, the efficacy and safety of NMN have been mixed; Secondly, NMN has not yet obtained licenses for drugs, health foods, food additives, or new food ingredients in China. On May 9, 2023, NMN was prominently listed on the official website of the National Health Commission as a product name for new types of food additives that are not subject to administrative licensing!
The regulatory oversight of NMNs worldwide is generally tightening. Japan is the first country in the world to approve NMN as a food ingredient, but in Australia, although NMN is approved as a therapeutic drug, it is only for export and not allowed to be sold domestically. The situation in the United States is relatively unique. NMN was once popular in the United States, but in 2022, the US FDA officially announced that NMN is no longer considered a dietary supplement, but a drug or ingredient that requires FDA approval. Once this regulation was exposed, it immediately dealt a catastrophic blow to the global NMN market.

As the NMN craze subsides, another anti-aging substance called ergothione is gradually emerging. It is the strongest natural antioxidant found in the human body at present. It is a small molecule amino acid. It was first found in the fungus Claviceps purpura in 1909. Because of its unique transport protein absorption mode, as well as the anti-aging mechanism directly to the mitochondria and the nucleus, it has been highly praised and studied by global anti-aging scientists. The most representative is Barry Halliwell of the National University of Singapore, who spent his life studying ergot sulfur. After the COVID-19, he also published a document, "The repair effect of ergot sulfur on the sequelae of COVID-19.". As of now, ergot sulfur has more than 10000 patents and multiple human clinical trials worldwide. Its safety, anti-aging mechanism, and multi-dimensional effects have been confirmed by the scientific community, and it is also known as the "longevity Vitamin".

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Ergothian is an anti-aging substance that has the same origin as cosmetics. In cosmetics, it has anti-aging, whitening, spot lightening, pore contraction, anti-inflammatory, and repairing effects. It was first introduced to the public by high-end skincare products from Est é e Lauder and Elizabeth Arden, both of whom use Ergothian as the most important antioxidant. In addition, there was a battle between Est é e Lauder and Oxis Interntioal over the mitochondrial protection patent of Ergothian. After many years, the two sides finally reached a settlement in 2010.
Ergosulfan has a wide range of research and applications in health products and food, including anti-aging, prolonging lifespan, oral beauty, improving brain cognition, eye protection, improving reproductive system health, protecting the liver, repairing post exercise damage, enhancing mitochondrial ATP, pet nutrition, and preservation. Scholars Makoto Katsube, Yukio Kato, and others from the Faculty of Pharmacy at Kanazawa University in Japan found that mice supplemented with ergothione at a dose of 4-5 mg/kg body weight per day had a 16% increase in median survival age and a 21% increase in average survival age. In addition to prolonging lifespan, oral administration of ergot can also improve the frailty of elderly mice; The kidney and liver functions of the mice were improved, and their motor and cognitive abilities were also better than those of the control group. In addition, the downward trend of SIRT6 protein levels in the experimental group mice was significantly reversed, which further confirms the significant effect of ergot sulfur in promoting body health and enhancing immunity.
At the same time, ergot can also increase the activity of telomerase, protect and prolong the length of telomeres, thereby promoting cell health and longevity. As is well known, the length of telomeres is closely related to aging and age-related diseases. In 2022, Priscilla Samuel et al. from the United States found that after treating cells with 0.04, 0.1, 0.3, or 1.0mg/ml ergothione for 8 weeks, under oxidative conditions, ergothione significantly extended the median telomere length and the 20th percentile telomere length, reduced the percentage of short telomeres (<3000 base pairs), and showed a significant difference in telomere shortening rate. Overall, it has been demonstrated that ergot sulfur is beneficial in reducing telomere shortening rate and preserving telomere length under oxidative stress conditions.
The study also found that ergot sulfur plays an important role in the prevention of elderly diseases, playing a preventive and therapeutic role in respiratory system diseases, nervous system diseases, digestive system diseases, cardiovascular system diseases, endocrine system diseases, eye diseases (dry eye syndrome, glaucoma), and elderly skin diseases, helping to extend the lifespan of the elderly. With the exacerbation of China's aging population, the national government is also encouraging the development of a silver haired economy to promote healthy and long life for the elderly, reduce social burden, and even create more value. This will undoubtedly bring immeasurable benefits to the entire society.

Numerous experiments have shown that ergot sulfur not only has similar functions to NMN, such as promoting energy metabolism and improving physical functions, but also performs better and is safer in anti-aging and antioxidant aspects. After thorough toxicological safety tests, ergot sulfur has been approved as a food ingredient by countries such as the United States, Europe, Canada, Australia, and Japan. On May 17, 2024, the Chinese Health Commission officially accepted the application for a new food ingredient for ergot sulfur.

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Due to the unique mechanism and efficacy of ergot, many synthetic biology companies have entered the production line of ergot. Among them, the biological ergotin Dr., a strategic cooperation between the Chinese Academy of Sciences Shanghai Institute of Organic Chemistry (hereinafter referred to as the Institute of Organic Chemistry of the Chinese Academy of Sciences) and Shanghai ergotin Biotechnology Group Co., Ltd. (hereinafter referred to as the Shanghai ergotin Group) Ergo ® is a leader in the industry, leading the way in creating high-purity crystalline ergot sulfur through its unique six technological routes and patented technologies in synthetic biology. Due to its unique transgranular structure, ergot sulfur has a more confidential and stable molecular encapsulation, with a purity of over 99.96%. Through high temperature, high humidity, and two years of room temperature stability experiments, it has been confirmed that ergot sulfur is caused by Dr The high stability and excellent quality of Ergo ®. Through the unremitting efforts of both parties, currently, ergot sulfur is due to Dr Ergo ® has obtained certifications from NSF's GMP, GRAS in the United States, NPH in Canada, and NOVEL FOOD in Europe, providing safety evidence and regulatory protection for market end applications.
Shanghai ergot sulfur group's ergot sulfur Dr Ergo ® has undergone years of intracellular and extracellular testing as well as human clinical trials, among which the most influential is the rare human oral beauty clinical trial on a global scale. The subjects took 25mg of ergot every day for four consecutive weeks. Before and after use, VISIA instruments were used to analyze data on wrinkles, textures, spots, pores, UV spots, brown spots, red areas, and purple substances. The results indicate that oral ergot sulfur has a significant impact on skin condition, especially in improving indicators of pigmentation, wrinkles, and pores, making it a potential active ingredient for oral beauty.

With the rapid development of the beauty economy and the health industry in recent years, the application of ergot in food, health products, cosmetics, medicine and other fields has gradually expanded. According to Early Data data, ergot in the oral beauty market increased by 6980% in 2023, demonstrating huge market potential. It is expected that in the coming years, with the improvement of production processes and the reduction of costs, especially the breakthrough of regulatory restrictions, the ergot sulfur component, which is homologous to cosmetics and food, is likely to become the next "anti-aging dark horse"!

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2024-06-20

Shaanxi Huike Botanical Development Co., Ltd.

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