Various problems that may be encountered in tablet candies and functional health food tablets

June 28, 2024

Tablets are solid formulations with a dense structure formed by the action of a tablet press on one or several powders. It has various shapes, beautiful appearance, accurate dosage, multiple administration routes, and can meet different clinical needs. It is one of the most important dosage forms in modern solid preparations.
The compression characteristics of tablet materials are usually a comprehensive reflection of multiple compression deformation mechanisms and various powder properties. The compression characteristics and flowability of tablet materials directly affect their adaptability to high-speed tablet production. Ideal tablet materials should have excellent flowability and compressibility.

The types of tablets include: oral tablets, chewable tablets, effervescent tablets, oral tablets, and orally disintegrating tablets; General raw and auxiliary materials include: active ingredients, fillers, lubricants, sweeteners, pigments, essence, stabilizers, effervescent agents, and disintegrants.

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01
Frequent problems of pressed candy essence

1. Selection principle of essence • Recommendation: oil soluble liquid essence is used, and the flavor is superior to powder essence, but powder essence can also be used • Recommendation: IFF, Chihuaton, Fenmeiyi • Prohibition: water-soluble essence
2. Common problems • The use of water-soluble essence causes agglomeration and hardening. The taste is slightly rough and the flavor is unnatural.
• Worried that the oil soluble liquid essence could not be mixed evenly, and dared not use it, so the taste could not reach the state of competitive products.

02
Lubricants (such as magnesium stearate) that are often prone to problems with pressed candies

1. Principles for the use of lubricants • Must: Lubricants such as magnesium hard acid need to be used and added immediately; • Must: Magnesium stearate needs to be added in the final stage of mixing; • Suggestion: The typical addition amount of magnesium hard acid is 0.8%, and if it is less than 0.5% or too much, the lubrication effect will decrease Suggestion: In some special tablets (standard effervescent tablets for solid drinks, soluble lubricants such as sucrose esters need to be considered)

2. Frequently asked questions • Do not let the material mixed with magnesium stearate stay overnight or delay for a longer time before pressing, as this can greatly affect compressibility Not adding magnesium stearate, or adding magnesium stearate in an amount greater than 2%

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03
The common problems with tablet candies and the tablet environment

1. Relative humidity • For materials such as sorbitol and xylitol that are prone to moisture absorption, the humidity in the experimental and production environment should be controlled within 40%, while other materials such as maltitol can be appropriately relaxed to 50%;
2. The ambient temperature for tablet pressing should be controlled within 25 degrees Celsius
3. How to improve environmental humidity and temperature • Dehumidification equipment (independent industrial dehumidifiers, preferably equipped in tablet workshops) • Air conditioning system • Choose seasons with dry weather and lower temperatures for staggered production
• Using moisture resistant materials

04
Pigment is a common problem with pressed candies

1. Recommended aluminum lake • Aluminum lake has the characteristic of uniform coloring, and the overall color of the tablet is transparent. Compared to environmental factors such as temperature, humidity, and oxygen, it has stronger stability Suggested source: Shanghai Dye Research Institute Co., Ltd

2. Common problems • Using some other types of powder pigments can result in poor mixing effect, spots, and uneven coloring; • Substances that are prone to oxidation and discoloration, such as VC, originally have no color and may have abnormal colors after storage or accelerated testing. It is necessary to add some similar colors to cover them. Some materials have deep colors and can easily cause significant spots. We generally recommend using finer maltitol or using further granulation processes.

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05
Formula design for the common detours in tablet candies

1. Investigation factors for excipient selection • Moisture absorption → consider anti hygroscopic materials • Antioxidation, heat sensitivity, photosensitivity → consider coating, reducing agent and other measures • Granularity, fluidity → difficulty in mixing → dose accuracy, color uniformity, taste, tablet weight stability of each tablet • effective dose of functional materials → design tablet weight, frequency of taking • taste, flavor, color of functional materials → essence, acid, pigment, coating, etc
2. Common problems are related to materials with extremely fine particle sizes ranging from 200 to 400 mesh, which usually have poor compressibility and require an increase in the proportion of auxiliary materials added;

Good fluidity is the key to reducing the above problems - angle of rest - Hausner Ratio - More advanced instruments include powder flow characteristic testers.

Shaanxi Huike Botanical Development Co., Ltd. a integrated enterprise which is focus on natural products, Plant extract related products and services.We mainly focus on pharmaceutical, functional food, Freeze-dried powder,Natural Pigment,Homology of medicine and food,beverages and other business services.
For more information about inulin, please contact us!

Email:marketing@huikes.com

2024-06-28

Shaanxi Huike Botanical Development Co., Ltd.

Author:

Ms. Anne

E-mail:

sales13@huikes.com

Phone/WhatsApp:

+8618591889792

Various problems that may be encountered in tablet candies and functional health food tablets

01 Frequent problems of pressed candy essence

02 Lubricants (such as magnesium stearate) that are often prone to problems with pressed candies

03 The common problems with tablet candies and the tablet environment

04 Pigment is a common problem with pressed candies

05 Formula design for the common detours in tablet candies

01
Frequent problems of pressed candy essence

02
Lubricants (such as magnesium stearate) that are often prone to problems with pressed candies

03
The common problems with tablet candies and the tablet environment

04
Pigment is a common problem with pressed candies

05
Formula design for the common detours in tablet candies